Deep genomic analysis of solid tumours
celldx is a tissue based comprehensive molecular profiling of solid tumours with the aim to personalise therapy options. The results are generally available within 8 working days and, in addition to the genetic analysis, also provide information on the benefit of immune checkpoint inhibitors.
About celldx
To individualise the cancer treatment, celldx detects genetic alterations suited for the application of targeted therapies. In addition, immunostaining is performed on the provided tissue samples for PD-L1 suitability in combination with tumour mutational burden and MMR.
celldx provides advantages whenever ...
... there has to be a fast decision about a targeted therapy.
... an immunotherapy is an option for the patient.
celldx provides deep molecular analysis for patients with advanced cancers.
SNVs | INDELs
442 Genes
SNV = Single nucleotid variation
INDEL = Insertion / Deletion
CNAs
417 Genes
CNA = Copy number alteration
FUSIONs
51 Genes
TMB
PD-L1
MMR
MMR = Mismatch repair
Comprehensive celldx
-
Indications
Non-Small Cell Lung Cancer (NSCLC)
BiomarkerEGFR Exon 19 deletions
EGFR Exon 21 L858R alterations
T790M
ALK rearrangements
BRAF V600E
ROS1 rearrangements
MET exon 14 skipping mutation/ MET gene amplification
NTRK fusions
PD-L1US FDA-approved TherapyAfatinib, Gefitinib, Osimertinib
Erlotinib, Dacomitinib
Osimertinib
Alectinib, Crizotinib, Ceritinib, Lorlatinib, Brigatinib
Dabrafenib in combination with Trametinib
Entrectinib, Crizotinib, Larlatinib, Ceritinib
Crizotinib
Larotrectinib, Entrectinib
Pembrolizumab, Nivolumab -
Indications
Colorectal Cancer (CRC)
BiomarkerKRAS wild-type (absence of mutations in exons 2, 3 and 4)
KRAS wild-type (absence of mutations in exons 2, 3 and 4) and NRAS wild-type (absence in mutations in exons 2, 3 and 4)
dMMRUS FDA-approved TherapyCetuximab
Panitumumab
Nivolumab ± Ipilimumab or Pembrolizumab -
Indications
Breast Cancer
BiomarkerERBB2 (HER2) amplification
PD-L1
BRCA1/2 alterations
PIK3CAUS FDA-approved TherapyLapatinib, Neratinib, Trastuzumab, Ado-trastuzumab, Emtansine or Pertuzumab
Atezolizumab
Olaparib, Talazoparib
Alpelisib -
Indications
Ovarian Cancer
BiomarkerBRCA1/2 alterations
US FDA-approved TherapyOlaparib, Rucaparib
-
Indications
Melanoma
BiomarkerBRAF V600E
BRAF V600E or V600KUS FDA-approved TherapyDabrafenib or Vemurafenib
Trametinib or Cobimetinib in combination with Vemurafenib -
Indications
Solid Tumours
BiomarkerNTRK
dMMRUS FDA-approved TherapyEntrectinib, Larotrectinib
Pembrolizumab -
Indications
Urothelial Carcinoma
BiomarkerFGFR2, FGFR3 gene alterations
PD-L1US FDA-approved TherapyErdafitinib
Pembrolizumab -
Indications
Prostate Cancer
BiomarkerAR
US FDA-approved Therapy -
Indications
Other cancers
BiomarkerERBB2 (HER2), BRCA1, BRCA2, PIK3CA, NTRK1, NTRK2 and NTRK3
US FDA-approved Therapy
FAQ
The turnaround time, after which the patient or his treating doctor will receive the results, is usually 8 working days from the day the laboratory receives the tissue sample. The test report contains all genomic highlights and lists the particular therapy options.
SNVs, INDELs, CNAs, Fusions, TMB, PD-L1, MMR, HRD (Homologous recombination deficiency).
Yes, celldx can provide information if a target alteration is present. Evaluation of therapies in the need of companion diagnostics across several cancer indications is available as well as clinical trial matching across all solid tumors.
celldx provides informed decisions if an immunotherapy is beneficial using genomic signatures like tumor mutational burden (TMB) and PD-L1 status via immunostaining.